Installing NI MultiSim and myDAQ, and Labview if you have the patience. The NI MultSim software only works under windows. Mac users will have to install windows using bootcamp if they want to run MultiSim.
However if you only want to use it with Labview or use the Virtual Instruments, Oscilloscope, Digital Multimeter etc. then there is a Mac version of the myDAQ driver it requires you to install Labview for Mac first. For more on using myDAC with a Mac.
Quick start guide to using NI MultiSim with myDAQ for circuit simulation and testing.